In the context of recurrent pregnancy loss, which condition is associated with risk factors such as Ehlers-Danlos syndrome?

Cervical insufficiency is the condition associated with recurrent pregnancy loss that has been linked to Ehlers-Danlos syndrome (EDS). EDS is a connective tissue disorder that can lead to structural abnormalities in the cervix, making it more prone to dilation and effacement before the fetus reaches term. This can result in premature delivery or miscarriage, as the cervical support mechanism is compromised due to the underlying connective tissue disorder.

In Ehlers-Danlos syndrome, the collagen abnormalities affect the strength and integrity of various tissues in the body, including the cervix. Women with this condition may present with a history of recurrent second-trimester losses due to cervical incompetence, as the cervix may not be able to withstand the pressure exerted by the growing pregnancy.

The other conditions listed do not have a direct or established association with Ehlers-Danlos syndrome in the context of recurrent pregnancy loss. They are more related to other factors such as maternal health, placental issues, or pregnancy-related complications rather than structural defects in connective tissues that impact cervical function.