What is the primary complication associated with untreated amenorrhea?

Untreated amenorrhea can lead to significant hormonal imbalances, primarily involving estrogen deficiency, which is crucial for maintaining bone density. When menstruation stops and is not addressed, the lack of estrogen can result in decreased bone mineral density over time, predisposing individuals to osteoporosis. This condition makes bones weak and susceptible to fractures, particularly in postmenopausal women or individuals with longstanding amenorrhea.

Although untreated amenorrhea can have other health complications, such as those relating to cardiovascular disease and reproductive cancers, osteoporosis is a direct consequence of long-term estrogen deficiency and is a primary concern, particularly in younger individuals who may not recognize the ongoing effects of amenorrhea on bone health. Therefore, focusing on the primary complication associated with untreated amenorrhea, osteoporosis stands out due to its long-term consequences and the relation to hormonal changes.